DARZALEX® + Velcade® (bortezomib) + dexamethasone
A multicenter, open-label, active-controlled phase 3 study1,2
- A majority (76%) of patients received prior treatment with an immunomodulatory agent
- More than half (69%) of patients received prior treatment with a proteasome inhibitor (PI)1
Patients were refractory to prior therapies1,2*
- 32% to the last line of treatment
33% to an immunomodulatory agent only
- 24% in the DARZALEX® + Vd arm and 33% in the Vd arm to lenalidomide
Baseline demographics were similar between arms1-3
The primary endpoint was PFS,† and the median follow-up was 7.4 months1,2
†Efficacy was evaluated by PFS based on International Myeloma Working Group criteria.1
Daratumumab (DARZALEX®) in combination with lenalidomide and dexamethasone, or bortezomib and dexamethasone, is recommended by the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) as a preferred Category 1‡ therapeutic option for previously treated multiple myeloma§
‡Category 1=based upon high-level evidence, there is uniform National Comprehensive Cancer Network® (NCCN®) consensus that the intervention is appropriate.
§Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Multiple Myeloma V.3.2017. © National Comprehensive Cancer Network, Inc. 2016. All rights reserved. To view the most recent and complete version of the guideline, go online to www.nccn.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.