DARZALEX® dosing

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DARZALEX® (daratumumab)

Dose DARZALEX® at 16 mg/kg of actual body weight as an intravenous (IV) infusion1

DARZALEX® dosing frequency decreases throughout the course of therapy1

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  • Administer DARZALEX® only as an IV infusion after dilution1
  • DARZALEX® should be administered by a healthcare professional with immediate access to emergency equipment and appropriate medical support to manage infusion reactions if they occur1
  • If a planned dose of DARZALEX® is missed, administer the dose as soon as possible and adjust the dosing schedule accordingly, maintaining the treatment interval1

Interference with Serological Testing

  • Daratumumab binds to CD38 on red blood cells (RBCs) and results in a positive Indirect Antiglobulin Test (Indirect Coombs test)
  • Daratumumab-mediated positive indirect antiglobulin test may persist for up to 6 months after the last daratumumab infusion
  • Daratumumab bound to RBCs masks detection of antibodies to minor antigens in the patient’s serum. The determination of a patient’s ABO and Rh blood type is not impacted
  • Notify blood transfusion centers of this interference with serological testing and inform blood banks that a patient has received DARZALEX®
  • Type and screen patients prior to starting DARZALEX®

Find out more about interference with serological testing for patients being treated with DARZALEX®

Provide this document to patients to let healthcare professionals know that the patient is being treated with DARZALEX®

 

Interference with determination of complete response1

  • Daratumumab is a human immunoglobulin G (IgG) kappa mAb that can be detected on serum protein electrophoresis (SPE) and immunofixation (IFE) assays, which can impact the determination of a CR and of disease progression in some patients with IgG kappa myeloma protein

 

DARZALEX® Interactive Calendar

 

Select the date on which you plan to initiate your patient’s first DARZALEX® infusion. Once a date is selected, recommended subsequent infusion dates will automatically populate within the calendar*

Select a date to begin

Select the date on which you plan to initiate your patient’s first DARZALEX® infusion. Once a date is selected, recommended subsequent infusion dates will automatically populate within the calendar*

Select a date to begin

Infusion Dates
Weeks 1-8
Weekly Infusions
Weeks 1-8 (weekly infusions)
Weeks 9-24
Infusions Every 2 Weeks
Weeks 9-24 (infusions every 2 weeks)
Weeks 25+
Infusions Every 4 Weeks
Weeks 25+ (infusions every 4 weeks)

*Please note that dates provided are recommendations for infusion visits only. These dates do not account for additional follow-up/care visits. Infusion dates may change depending on patient and office availability.

Infusion centers may not offer weekend and/or holiday appointments.

Please contact the center to confirm hours of operation.

You have chosen a new start date.

Would you like to clear your old dosing schedule and create a new one?

Please select the date you plan to give the patient as first DARZALEX® dose.
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DARZALEX® Monotherapy
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