DARZALEX® + Rd dosing

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DARZALEX® + Revlimid® (lenalidomide) + dexamethasone

DARZALEX® dosing frequency decreases throughout the course of therapy1

  • DARZALEX® is given as an intravenous (IV) infusion after dilution at 16 mg/kg of actual body weight
  • Lenalidomide is given orally on days 1–21 of each cycle*
  • Dexamethasone is given orally or IV once a week
    • On DARZALEX® infusion days, 20 mg of the dexamethasone dose was given as a pre-infusion medication and the remainder given the day after the infusion

Want a PDF of the DARZALEX® + Rd dosing schedule?

Looking for a comprehensive guide with DARZALEX® dosing & administration?

  • DARZALEX® should be administered by a healthcare professional with immediate access to emergency equipment and appropriate medical support to manage infusion reactions if they occur1
  • If a planned dose of DARZALEX® is missed, administer the dose as soon as possible and adjust the dosing schedule accordingly, maintaining the treatment interval1

Interference with Serological Testing

  • Daratumumab binds to CD38 on red blood cells (RBCs) and results in a positive Indirect Antiglobulin Test (Indirect Coombs test)
  • Daratumumab-mediated positive indirect antiglobulin test may persist for up to 6 months after the last daratumumab infusion
  • Daratumumab bound to RBCs masks detection of antibodies to minor antigens in the patient’s serum. The determination of a patient’s ABO and Rh blood type is not impacted
  • Notify blood transfusion centers of this interference with serological testing and inform blood banks that a patient has received DARZALEX®
  • Type and screen patients prior to starting DARZALEX®

Find out more about interference with serological testing for patients being treated with DARZALEX®

Provide this document to patients to let healthcare professionals know that the patient is being treated with DARZALEX®

 

DARZALEX® + Rd Interactive Calendar

 

Select the date on which you plan to initiate your patient’s first DARZALEX® infusion. Once a date is selected, recommended subsequent infusion dates will automatically populate within the calendar.

Select a date to begin

Select the date on which you plan to initiate your patient’s first DARZALEX® infusion. Once a date is selected, recommended subsequent infusion dates will automatically populate within the calendar.

Select a date to begin

Infusion Dates
Weeks 1-8
Weekly Infusions
Weeks 1-8 (weekly infusions)
Weeks 9-24
Infusions Every 2 Weeks
Weeks 9-24 (infusions every 2 weeks)
Weeks 25+
Infusions Every 4 Weeks
Weeks 25+ (infusions every 4 weeks)

Please note that dates provided are recommendations for infusion visits only. These dates do not account for additional follow-up/care visits. Infusion dates may change depending on patient and office availability.

Infusion centers may not offer weekend and/or holiday appointments.

Please contact the center to confirm hours of operation.

You have chosen a new start date.

Would you like to clear your old dosing schedule and create a new one?

Please select the date you plan to give the patient as first DARZALEX® dose.
Please choose a dosing regimen.
DARZALEX® + Revlimid® (lenalidomide) + dexamethasone
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Please select the view mode for your dosing calendar.

Looking to give this dosing schedule to your patient?